Synthetic Gene for Placental Uteroferrin

Phase I will use a synthetic gene approach for high-yield expression of human uteroferrin protein iand to assess its potential for hematopoietic growth factor (HGF) effects in stimulating bone marrowcirculating progenitor cells to expand and to differentiate into mature hematopoietic cells. From clHGF's, patients under high-dose cancer therapy can benefit greatly from the higher number of hematopby the administered factor. We have demonstrated that both human and porcine uteroferrin have HGF acstimulate progenitor cells and to generate a wide range of mature blood cells than any known HGFs. Udemonstrated to be able to prevent the decrease of colony-forming units in 5-fluorouracil-treated pimerit a further effort to develop uteroferrin as a hematopoietic growth factor to help patients undebone marrow transplant and other blood-related diseases.