INFORMATION RESOURCE ACTIVITIES IN CHEMOPREVENTION LITERA- TURE

THE OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT OF A COMPREHENSIVE INFORMATION RESOURCE ON CHEMOPREVENTION THAT MAY BE APPLIED TO THE IDENTIFICATION OF CHEMOPREVENTIVE AGENTS AND TO OTHER RESEARCH AND DEVELOPMENT PROBLEMS IN CHEMOPREVENTIOTHE DEVELOPMENT OF CHEMOPREVENTIVE AGENTS IS A HIGH-PRIORITYRESEARCH EFFORT AT NCI, PARTICULARLY FOR AGENTS THAT ARE EF-FICACIOUS AND SAFE FOR USE IN PATIENTS AT HIGH RISK FOR DEVELOPING CERTAIN TYPES OF CANCERS. A PRIMARY RESULT OF PHASE I OF THIS PROJECT WAS THE DEVELOP-MENT OF A MASTER LIST DATABASE OF 543 POTENTIAL CHEMOPREVEN-TIVE AGENTS, WITH INDICATORS OF EFFICACY AND LITERATURE REF-ERENCES. THE INFORMATION ON EFFICACY INCORPORATED INTO THIS DATABASE WAS THAT INFORMATION JUDGED TO BE MOST USEFUL TO NCI IN PRIORITIZING AGENTS FOR FURTHER STUDY. IN PHASE II, THE MASTER LIST DATABASE WILL BE UPDATED, AND DATABASES OF EFFICACY TEST RESULTS (ANIMAL BIOASSAYS, SHORT-TERM TESTS, EPIDEMIOLOGY, INTERMIDIATE MARKERS) AND TOXICITY WILL BE DEVELOPED FOR THE AGENTS INCLUDED IN THE MASTER LIST. THESE DATABASES ARE EXPECTED TO BE APPLIED TO VARIOUS ASPECTS OF RESEARCH AND DEVELOPMENT PLANNING FOR BOTH NCI AND COMMER- CIAL CLIENTS. POTENTIAL APPLICATIONS INCLUDE STRUCTURE-AC- TIVITY STUDIES, ESTABLISHING TESTING PRIORITIES, AND EVAL- UATING THE RELIABILITY OF VARIOUS TESTING PROTOCOLS.