COMPUTER ANALYSIS OF DNA AND PROTEIN SEQUENCE DATA HAS BECOME ESSENTIAL TO RESEARCH IN MODERN MOLECULAR BIOLOGY.

COMPUTER ANALYSIS OF DNA AND PROTEIN SEQUENCE DATA HAS BECOME ESSENTIAL TO RESEARCH IN MODERN MOLECULAR BIOLOGY. SOFTWARE TOOLS ARE USED FOR THE DESIGN OF EXPERIMENTS, THE ACQUISITION OF DATA, AND FOR ANALYSIS OF SEQUENCE DATA, AS EXEMPLIFIED BY THE UNRAVELING OF THE RELATIONSHIPS BETWEEN NORMAL CELLULAR GENES AND ONCO-GENES. FOR PHASE I, WE WISH TO ADD LARGE DATABASE CAPACITY IN A USEFUL FORM TO OUR CURRENTLY AVAILABLE PROGRAM PACKAGE. BY USEFUL, WE MEAN THE COMPLETE GENBANK NUCLEIC ACID DATABASE AND NBRF PROTEIN DATABASE WITH ANNOTATION. WE MEAN THE ABILITY TO ACCESS ANY ENTRY, OR ANY PART OF ANY ENTRY, FROM ANY PROGRAM IN LESS THAN 10 SECONDS ON AN IBM PC OR COMPATIBLE; AUTOMATIC ANNOTATION OR TRANSLATION OF SEQUENCES USING THE SITES/FEATURES TABLES; ACCESS TO GROUPS OF ENTRIES BY ORGANISM, TYPE OF GENE, AUTHOR, KEYWORD, OR ACCESSION NUMBER; AND NO LIMIT TO LENGTH OF SEQUENCE ACCEPTED. FOR PHASE II, WE WILL EXPAND THE AUTOMATIC AND EASE OF USE FEATURES TO A SELF-ANNOTATING MULTIWINDOW SEQUENCE EDITOR WITH AUTOMATIC SEQUENCE ASSEMBLY, AND SELF-ANNOTATION TO OUR CURRENT ANALYTICAL PROGRAMS, ETC. WE WILL ALSO MOVE THE SOFTWARE TO MC68000 BASED MICROCOMPUTERS AND TO THE UNIX MULTIUSER OPERATING SYSTEM.