MEASUREMENT SYSTEM FOR PASSIVE RESPIRATORY MECHANICS

THE LONG-TERM OBJECTIVE OF THE PROJECT IS TO DEVELOP AN AUTOMATED, SIMPLE-TO-USE SYSTEM FOR THE MEASUREMENT OF RESPIRATORY MECHANICS IN NEWBORNS AND CHILDREN WITH A PASSIVE EXPIRATORY MANEUVER. FLOW VOLUME MEASUREMENTS FOLLOWING RELAXATION OF THE RESPIRATORY MUSCLES WITH THE HERING-BREUER REFLEX ALLOW FOR CALCULATION OF TOTAL COMPLIANCE AND RESISTANCE USING THE END INSPIRATORY PLATEAU PRESSURE AS MEAN PLEURAL PRESSURE. PREVIOUSLY DESCRIBED APPLICATION OF THIS TECHNIQUE USED MANUAL CONTROLS FOR SHUTTER CLOSURE AND DATA ANALYSIS, EXCLUDING THE METHOD TO ONLY RESEARCH APPLICATIONS. SPECIAL DESIGN CONSIDERATIONS HAVE PROVISIONS FOR MANAGING THE LOW DEADSPACE REQUIREMENTS OF THE PATIENT POPULATION AND PRODUCING AIRWAY OCCLUSION WITHOUT INDUCING PRESSURE ARTIFACTS. AN AUTOMATED SYSTEM WOULD PLACE THIS TECHNIQUE WITHIN THE REACH OF CLINICIANS FOR THE DIAGNOSIS AND MANAGEMENT OF NEWBORNS AND INFANTS WITH ALTERED LUNG FUNCTION.