SBIR/STTR Research Award
A Set of Mapping Panels for Localizing Human Genetic Diseases
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1993Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- C-MOTION, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- GJPLU1M2BUE5
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
The objective of this proposal is to develop and distribute a set of mapping panels for all human autosomes and the X chromosome. These mapping panels, consisting of 300-400 highly polymorphic loci spaced at 10-15 centiMorgan (cM) intervals, will provide the necessary tools for an efficient, and cost effective, search of the genome for markers linked to human diseases. With recent progress in the development of microsatellite markers that can be typed using the polymerase chain reaction (PCR), a large number of high quality markers will soon be available for use in disease gene mapping. A subset of these that will be sufficient to span a chromosome and will be robust for the collection of genotypic data will be selected for the mapping panels. During Phase I, mapping panels for human chromosomes 10 and 20, consisting of 17-25 and 10-15 markers, respectively, will be developed. Markers with heterozygosities = 0.70 will be selected at 10-15 cM intervals based on their reliability and efficiency of use, following a thorough PCR evaluation. Multipoint maps, including loci in the mapping subset and higher resolution maps, will be constructed.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- A Probabilistic Pose Estimation Algorithm for D Motion Capture Data
- Software for improved accuracy and rapid tracking of kinematics from dynamic Xray
- Multivalent Growth Factor Conjugates to Accelerate Wound Neovascularization in El
- Development of a Low Cost, Real-time Biofeedback Gait Retraining System
- A Probabilistic Pose Estimation Algorithm for 3D Motion Capture Data
Research funding history
40 SBIR/STTR records share this UEI (1984–2016). Reported award amounts total $7,496,526. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services