SBIR/STTR Research Award

ANALYSIS OF THE IMMUNOGLOBULIN HYPERMUTATOR MECHANISM

Award identifier 5ecef26072c8bf249890e06799d2dfab6bc0d81a1895dbddea6d1817e4683a50Awarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1992

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
STRATAGENE
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

THE GOAL IS TO DEVELOP AN ASSAY THAT CAN BE UTILIZED BOTH IN VIVO AND IN VITRO FOR RAPIDLY MONITORING HYPERSOMATIC MUTATION EVENTS WITHIN IMMUNOGLOBULIN GENES. THE AVAILABILITY OF SUCH AN ASSAY IS ESSENTIAL FOR CHARACTERIZING THE ANTIBODY MUTATOR ACTIVITY AND DETERMINING WHICH FACTORS MODULATE ITS ACTIVITY. THIS SYSTEM SHOULD ULTIMATELY LEAD TO THE DEVELOPMENT OF AN IN VITRO SYSTEM FOR AFFINITY MATURATION OF LOW AFFINITY ANTIBODIES.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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