SBIR/STTR Research Award
EXPRESSION OF DENGUE 3 ENVELOPE AND NONSTRUCTURAL 1 GLYCOPROTEINS IN THE FUNGUS NEUROSPORA CRASSA
Award amount
$67,723Program and phase
SBIR · Phase IAward year
1990Award details
- Awarding agency
- Department of Defense
- Branch
- Army
- Recipient company
- HAWAII BIOTECH, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- ECJKEEFL4L51
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE FOUR SEROTYPES OF DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. FOR THE DEVELOPMENT OF DIAGNOSTICS FOR AND SUBUNIT VACCINES AGAINST DENGUE VIRUS, A RELIABLE AND INEXPENSIVE SOURCE OF DENGUE PROTEINS IS NEEDED. THE EXPRESSION OF RECOMBINANT PROTEINS IN MICROORGANISMS OFFER SIGNAITICANT ADVANTAGES TO PURIFICATION OF NATIVE VIRAL PROTEINS. WE PROPOSE TO EVALUATE THE USE OF THE FUNGUS NEUROSPORA CRASSA TO PRODUCE AUTHENTIC DENGUE 3 ENVELOPE AND NONSTRUCTURAL 1 GLYCOPROTEINS.THE SEQUENCES ENCODING THESE PROTEINS WILL BE PLACED UNDER THE TRANSCRIPTIONAL CONTROL OF A CONSTITUTUVE NEUROSPORA PROMOTER, EITHER WITH THEIR OWN SECRETION SIGNAL PEPTIDES OR WITH A HETEROLOGOUS SIGNAL PEPTIDE. THE PROTEIN PRODUCED WILL BE EVALUATED WITH RESPECT TO MOLECULAR WEIGHT, GLYCOSYLATION AND ANTIGENICITY.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Chikungunya Recombinant Subunit Vaccine
- Development of a Cross-Protective New World Encephalitic Alphavirus Subunit Vaccine
- Novel TLR-4 Agonists as Vaccine Adjuvants
- RECOMBINANT WEST NILE VIRUS VACCINE ADJUVANTED WITH SLA-LSQ
- Chikungunya Recombinant Subunit Vaccine
Research funding history
103 SBIR/STTR records share this UEI (1983–2024). Reported award amounts total $40,917,853. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services, Department of Defense, National Science Foundation, Department of Agriculture