SBIR/STTR Research Award
Development of C Labeled Nitrons
Award amount
$93,083Program and phase
SBIR · Phase IAward year
1995Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Le Research, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
Some nitrone spin traps have been found to possess many potentially useful pharmacological propertilowering septic shock fatality, reversing the effects of aging, cardioprotection, and vasodilation.dispositon and metabolism in the development of these compounds as new drugs require the nitrone comwith carbon-14. We will develop the preparative steps for a-phenyl-N-t-butylnitrone-a-14 C, 5,5-dimeoxide-a-14 C, and 4-bromomethylpyridine-a-14 C which is a precursor to a-(4pyridyl-1-oxide)-N-t-butyPhase II will complete the synthesis of 4-POBN-a-14C and pursue the 14C-labeled versions of other pr
Technology keywords
Not reported