VACCINATION AGAINST HOOKWORM WITH RECOMBINANT ANTIGENS

Not Available Chemical weapons are highly lethal, inexpensive weapons of mass destruction. Present methods for detection of exposure to sulfur mustard are expensive and time-consuming. Accordingly, there is an urgent need for the development of rapid, simple, and reliable detection methods capable of monitoring of toxic compounds for clinical treatment and diagnosis after exposure to sulfur mustard. In phase I, we propose the syntheses of four analogs of bis ((2-acetylamino-2-carboxyethylthio) ethyl) sulfone and their conjugates with two carrier proteins (KLH and BSA) for production of antibodies and immunoassay development. Haptens will be coupled with carrier proteins through either the central sulfur atom or terminal amino group via a linker. BENEFITS: An immunoassay for rapid determination of exposure to sulfur mustard would contribute to improved diagnosis and treatment of individuals during military or terroristic acts.