Selective Sensor for Prediction of Neonatal Jaundice

An electrochemical sensor system will be developed to measure carbon monoxide in the 0-10 part-per-million range in the presence of 0-200 ppm of hydrogen gas. Since carbon monoxide is generated during heme degradation and exhaled, this system will be useful for the prediction of neonatal jaundice. However, electrochemical measurements are often confounded by exhaled hydrogen form intestinal microflora. The sensor "system" may consist of a selective permeation device that precedes a standard sensor or a selective absorption device (such as a simplified gas chromatograph). We will investigate the potential of developing a new type of sensor that is inherently insensitive to hydrogen.