SBIR/STTR Research Award
Radioprotective mimetics of fibroblast growth factors
Award amount
$99,750Program and phase
SBIR · Phase IAward year
2003Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- BIOSURFACE ENGINEERING TECHNOLOGIES
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
DESCRIPTION (provided by applicant): We propose to develop and evaluate peptide mimetics of growth factors within the fibrobtast growth factor family. We have designed and produced the first ever synthetic multi-domain peptides, F2A3 and F2A4, that mimic natural FGF-2 and stimulate the biological activity of the FGF receptor. We will expand on this to build peptide mimetics of FGF-1 and FGF-7. The new variants will be evaluated and compared to their recombinant FGF counterparts as well as our current FGF-2 mimetics in a variety of biochemical and cellular assays.
Technology keywords
Not reported