SBIR/STTR Research Award

IMMUNOISOLATED CELL TRANSPLANTS FOR TREATMENT OF PARKINSON'S DISEASE

Award identifier 99b804f0bc48b4000aeb713487d0acd1d19c39fea27b281418760de448ae6fe0Awarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1990

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
Cellular Transplants Inc
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

STRIATAL TRANSPLANTATION OF NEUROTRANSMITTER CELLS, IMMUNOISOLATED WITHIN A PERMSELECTIVE POLYMER MEMBRANE CAPSULE, REPRESENTS A NOVEL APPROACH TO THE TREATMENT OF PARKINSON'S DISEASE. THE TECHNIQUE HAS HAD PROMISING RESULTS IN SEVERAL RODENT MODELS, AND PRIMATE STUDIES ARE UNDERWAY. THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO COMPLETE THE DEVELOPMENTS NECESSARY FOR WIDESPREAD MEDICAL ACCEPTANCE OF IMMUNOISOLATED CELLULAR TRANSPLANTATION IN THE TREATMENT OF NEURAL DISEASES. ONE UNACHIEVED PREREQUISITE TO SUCH ACCEPTANCE IS UNEQUIVOCAL DEMONSTRATION OF CAPSULE INTEGRITY AND COMPLETE SEGREGATION OF THE FOREIGN MATERIAL FROM THE HOST. ACCORDINGLY, THE SPECIFIC OBJECTIVE OF THIS PROJECT IS TO DEVELOP AND VALIDATE AN IN VIVO ASSAY OF INDIVIDUAL CAPSULE INTEGRITY BASED UPON ANTIBODY-MEDIATED COMPLEMENT LYSIS OF ENCAPSULATED PC12 CELLS.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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