SBIR/STTR Research Award

STTR Phase I: High Pressure Disaggregation of IVIg Formulations For Increased Yield and Safety

Award identifier b2dc286bee9fcc676a212b7fbee3e8d484bb78819c8a16fe065d3a203bb6d5b5Awarding agency National Science Foundation

Award amount

$98,181

Program and phase

STTR · Phase I

Award year

2004

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Award details

Awarding agency
National Science Foundation
Branch
Not reported
Recipient company
BaroFold, Inc.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

This Small Business Technology Transfer Research (STTR) Phase I project proposes to use high pressures for disaggregation and proper refolding of aggregated proteins in commercial IVIg (immunoglobins for intravenous administration) formulations.The commercial application of this project will be in improved quality of therapeutic proteins for intravenous administration. Increased process yields will lower patient costs for IVIg therapies, and IVIg formulations with dramatically diminished aggregate content will lower side effects and reduce the risk of severe complications.

Technology keywords

Not reported

Agency intelligence

National Science Foundation

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