SBIR/STTR Research Award
MINIATURE DIAGNOSTIC DEVICE FOR SERUM CHOLESTEROL
Award amount
$500,000Program and phase
SBIR · Phase IIAward year
1990Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Enzymatics, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A MINIATURE, INSTRUMENT-INDEPENDENT, QUANTITATIVE DIAGNOSTIC DEVICE FOR PLASMA CHOLESTEROL THAT IS SUITABLE FOR CHOLESTEROL DETERMINATION IN THE HOME OR THE DOCTOR'S OFFICE. PHASE I RESEARCH DEALS WITH COMBINING A PREVIOUSLY DEVELOPED CHOLESTEROL-SPECIFIC ANALOG-TO-DIGITAL CHEMICAL COLOR SWITCH WITH CHOLESTEROL ESTERASE ACTIVITY TO BUILD A REACTION MATRIX THAT WILL ACT ON LIPOPROTEIN CHOLESTEROL ESTERS, AS WELL AS FREE CHOLESTEROL IN LIPOPROTEIN PARTICLES. OPTIMIZATION OF THE SYSTEM USING THE SEQUENTIAL SIMPLEX METHOD WILL ALSO BE UNDERTAKEN. PHASE I RESEARCH WILL DEMONSTRATE THE FEASIBILITY OF BUILDING THE CHOLESTEROL DIAGNOSTIC DEVICE, BASED ON THE ANALOG-TO-DIGITAL COLOR SWITCH. SUBSEQUENT PHASES WILL REDUCE THE WET CHEMISTRY TO A DRY FORMAT AND PRODUCE PROTOTYPE DEVICES.
Technology keywords
Not reported