SBIR/STTR Research Award

CHEMOTHERAPY OF LEISHMANIA WITH OLIQODEOXYNUCLEOTIDE PROBES

Award identifier 30ebe71e8512746d07b294c79af9f41c5b2b49ce6e010366dc60a641f88e5f8fAwarding agency Department of Defense · Army

Award amount

$563,537

Program and phase

SBIR · Phase II

Award year

1990

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Award details

Awarding agency
Department of Defense
Branch
Army
Recipient company
Epoch Pharmaceuticals, Inc.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

WE WILL INVESTIGATE THE ABILITY OF OLIGODEOXYNUCLEOTIDES COMPLEMENTARY TO THE SPLICED LEADER SEQUENCE OF LEISHMANIA ENRIETTII TUBULIN MRNA'S TO INHIT TRANSLATION AND TO KILL THE CELLS IN CULTURE. VARIOUS CHEMICAL MODIFICATIONS WILL BE MADE TO ENHANCE THE EFFECT OF THE OLIGOS. SUCCESSFUL AGENTS MAY BE VALUABLE, SELECTIVE CHEMOTHERAPEUTIC AGENTS AGAINST OTHER LEISHMANIA SPECIES IF MAD COMPLEMENTARY TO MRNA LEADERS FROM THOSE SPECIES.

Technology keywords

Not reported

Agency intelligence

Department of Defense

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