Continuous Flow Centrifugal Membrane Separator

Current centrifugation and filtration methodologies in the bioprocess separation train cause probleproduct loss due to contamination, degradation, equipment fouling, and high shear force induced cellamplify downstream fouling of expensive purification equipment and processes, ultimately resulting idegradation and contamination. Typically, centrifugation equipment requires significant expendituresmaintenance validation and offers little portability. Centracept's proposed scaleable centrifuge desboth centrifugation and filtration principles in the same continuous process step. This allows for ashear forces that are just high enough to prevent filter fouling or blinding, but low enough to avoithis configuration, larger particulate (cells) are separated by the membrane and collected by centrifree filtrate is allowed to pass through the filter membrane. The separation chamber uses a closed,that requires no rotating seals. Use of a disposable allows for reagent rental usage financing and mrepeated CIP/SIP validation documentation.