SBIR/STTR Research Award
Improved Protease Inhibitor Therapy for AIDS
Award amount
$100,000Program and phase
SBIR · Phase IAward year
1995Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Sts Duotek, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
Our company will formulate a protease inhibitor, KNI-272, to improve bioavailability following oraladministration. This will be accomplished using patented technology to convert this nearly water-insspherical, amorphous, uniformly-sized submicron particles suspended in a biocompatible aqueous mediuhas been used to produce formulations for anti-cancer and antimicrobial therapy with improved oral bformulation of KNI-272 will be subjected to preliminary bioavailability evaluations in mice to demonPhase II objectives will focus on preclinical efficacy and toxicity studies following oral administrbenefits of intravenous administration. In Phase III, clinical trials will be carried out.
Technology keywords
Not reported