SBIR/STTR Research Award
GIGAPOROUS PARTICLES FOR PREPARATIVE SEPARATIONS
Award amount
$139,350Program and phase
SBIR · Phase IAward year
2001Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- FENRIS TECHNOLOGY
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
DESCRIPTION: (Applicant's description) The Fenris Technology Research, Inc.,
proposes to develop gigaporous polymer particles to be used as stationary
phases for preparative liquid chromatography. They will be designed to contain
large pores in order to allow mobile phase to flow through the particles at a
rate fast enough for convective mass transfer in the stationary phase to exceed
diffusive mass transfer. Under these conditions, plate height does not increase
with flow velocity making it possible to conduct efficient separations at a
high flow rate. This is particularly important for preparative separations of
proteins and other macromolecules with small diffusion coefficients. The Phase
I objectives are to demonstrate that it is feasible to prepare polymer
particles of known high porosity and is possible to control and vary the
porosity by appropriate choice of formulation. The mechanical and permeability
properties of these particles will be investigated.
PROPOSED COMMERCIAL APPLICATION:
The materials to be prepared in this research program will be useful as stationary phases
for preparative chromatography. They are particularly well-suited for purifying proteins
and other high molecular weight biomolecules.
Technology keywords
Not reported