SBIR/STTR Research Award
Detection of Pyrimethamine Malaria by LCR
Award amount
$98,113Program and phase
SBIR · Phase IAward year
1995Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Bioserve Biotechnologies, Ltd.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
We will develop a ligase chain reaction (LCR) method to detect mutations in the dihydrofolate reducgene of Plasmodium falciparum. Mutations at codon 108 of this gene have been shown to correlate withresistance. The specific aims of the project are to develop an LCR method for detection of DHFR mutamethod against both known drug sensitive and resistant isolates and assay uncharacterized isolates fTechnical innovations would be introduced to make the assay rapid, affordable, and easy to perform a
Technology keywords
Not reported