Portable Fiber Lasers for Multiphoton Endoscope

DESCRIPTION (provided by applicant): An all-fiber-based multiphoton endoscope will be developed for acquiring in vivo MPM signals from tissues. A femtosecond fiber laser and a small fiber probe will make it possible to detect MPM signals from small areas o f internal cavities and organs. PolarOnyx proposes to develop an innovative high power femtosecond fiber laser with fiber delivering of undistorted femtosecond light pulses to tissues and a fiber bundle for collecting MPM signals excited from tissues. Usi ng all-fiber-based components, the system will be compact, portable, and low-cost. In phase I, a femtosecond fiber laser will be developed and optimized for MPM applications. A miniature probe head will be designed to deliver excitation light and collect s ignals. Laser beam will be scanned in depth and multiphoton spectra will be acquired using a spectrograph. In phase II, the laser will be fully optimized and integrate with the fiber probe towards real clinic try.