WE INTEND TO INVESTIGATE THE POTENTIAL FOR LIPOSOME ENCAPSULATION OF LYMPHOTOXIN AND ITS DELIVERY TO SPECIFIC LIVER CELLS WHERE LYMPHOTOXIN CAN AUGMENT A NATURAL RESPONSE AGAINST TUMOR.

WE INTEND TO INVESTIGATE THE POTENTIAL FOR LIPOSOME ENCAPSULATION OF LYMPHOTOXIN AND ITS DELIVERY TO SPECIFIC LIVER CELLS WHERE LYMPHOTOXIN CAN AUGMENT A NATURAL RESPONSE AGAINST TUMOR. UNDERSTANDING HOW THE HOST'S NATURAL DEFENSE SYSTEM CAN BE MODULATED BY CHEMOTHERAPEUTIC DRUGS AND BRMS IN A NUMBER OF PATHOLOGIC STATES IS CRITICAL IN DETERMINING THEIR CLINICAL USEFULNESS. SINCE THE LIVER IS A MAJOR TARGET OF INVASION BY METASTATIC TUMORS, WE HAVE SELECTED IT AS A MODEL ORGAN TO ACCOMPLISH OUR RESEARCH AIMS. WE HAVE DEVELOPED, AND WILL EMPLOY IN THIS PROJECT, TECHNIQUES TO STUDY THE LIVER'S NATURAL ANTITUMOR DEFENSE SYSTEM IN VITRO/EX VITRO AS WELL AS METHODS TO TARGET IMMUNOENHANCING AGENTS TO VARIOUS REGIONS OF THE MURINE LIVER USING LIPOSOMES OF VARIED SIZE AND COMPOSITION.