SBIR/STTR Research Award
A Low Cost Integrated Method for Isolation of M. Tuberculosis DNA from Raw Sputum
Award amount
$2,999,954Program and phase
SBIR · Phase IIAward year
2019Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- AKONNI BIOSYSTEMS INC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- PGLAYC4UKDL7
- Solicitation number
- Not reported
- Topic code
- NIAID
Research abstract
Nucleic acid testing offers the potential to improve tuberculosis diagnosis world wideHigh purity DNA is essential to the success of virtually any downstream nucleic acid detection methodWe propose to develop a sample preparation system to extract and purify Mycobacterium tuberculosis DNA from raw sputumThe project goalas described in the solicitationPHSTopicis to develop an inexpensive and easy to use sputum processing system that can operate in a low resource clinic setting for downstream molecular testingWe plan to meet the following objectives over the course of this projectStreamline the workflow to improve the ease of use and meet the intended use settingDesign and produce the device and consumables under Design Control using good manufacturing processes to meet ISOrequirementsVerify the device function relative to its product requirementsValidate the device with raw sputum specimens using a PCR MTB test to determine the clinical sensitivity and specificity as compared to a standard laboratory methodandImplement a Quality Program for the sample preparation device to ensure lot to lot consistency
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Lab-on-a-Film Multiplexed Test for Respiratory Mycobacterial Infections
- Lab-on-a-Film Multiplexed Test for Respiratory Mycobacterial Infections
- Lateral flow array for undeclared food allergens
- TB Diagnostics at the Point of Care
- SAMPLE PREPARATION AND SCREENING OF NON INVASIVE PEDIATRIC SPECIMENS FOR LOWER RESPIRATORY DISEASE
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Manufacturing and Formulation Process Development for a Prophylactic Cholera Phage Cocktail
- A first-in-class product for the clearance of high-risk human papillomaviruses
- A Rapid, Point-of-Care Diagnostic to Identify Viable Sexually Transmitted Infections, Reduce Overtreatment, and Prevent Emerging Antibiotic Resistance
- Optimization, Pharmacokinetics, and Efficacy of an IgG Protease for the Treatment of Immune Thrombocytopenia and Other IgG-Mediated Autoimmune Diseases
- Nebulized ALX1 as a treatment for Pseudomonas aeruginosa infections in bronchiectasis patients
Research funding history
24 SBIR/STTR records share this UEI (2006–2022). Reported award amounts total $23,362,860. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, National Science Foundation, Department of Energy