LOW COST, SEQUENCE BASED CANCER PHARMACOGENETICS

Not Available Laser Fare-Advanced Technology Group (LF-ATG) has teamed with Triton Systems, Inc. (Triton), and Molecular Geodesics, Inc. (MGI), to propose an innovative method for producing multi-material structures that arrest the propagation of acoustic or vibrational energy. The approach forms scattering centers using Laser Engineered Net Shaping (LENS). The scattering elements will be intrinsically periodic due to their layered build format and geometric structure. With proper choice of material densities and elastic moduli, destructive interference of longitudinal and transverse acoustic waves over a specific frequency range has been demonstrated in simple periodic structures (Refs. 1-3). LF-ATG and Triton have applied the LENS solid freeform (SFF) method to generate titanium matrix composites (Ref. 4). We anticipate adapting LENS to provide a more diverse range of materials and periodic geometries in the design, fabrication and test of composite devices that are opaque to mechanical vibrations over a significantrange of frequencies. As shown in this proposal, our approach can achieve precise tailoring of the spatial distribution of the scattering / phase shifting materials in millimeter to tens of centimeter-scale structures. This will potentially enable acoustic and vibration isolation in multiple directions at frequencies ranging from the audible to the ultrasonic.