INSTRUMENTATION FOR MULTI-ISOTOPE BETA-GAMMA DETECTION

APPLIED RESEARCH CORPORATION PROPOSES THE DEVELOPMENT OF A NOVEL TECHNIQUE FOR CONSIDERABLY INCREASING THE SPEED AND EFFICIENCY OF DNA SEQUENCING. THIS TECHNIQUE IS BASED ON MULTIPLE ISOTOPIC DETERMINATION USING B( )/( ) COINCIDENCE AND CAN BE EXTENDED TO ANALYZE THE OUTPUT OF OTHER FRACTIONATION PROCESSES, E.G., COLUMN CHROMATOGRAPHY. THE PROPOSED SYSTEM: IS FULLY AUTOMATED; PERMITS MULTI-ISOTOP IMAGING; PROVIDES SIZE AND SPATIAL RESOLUTION COMPARABLE TO NUCLEAR EMULSIONS;AND AFFORDS QUANTUM DETECTION EFFICIENCY ORDERS OF MAGNITUDEBETTER THAN "AUTORADIOGRAPHY". THE USE OF 15 ISOTOPES OF BROMINE/IODINH PROMISE ORDERS OF MMAGNITUDE ACCELERATION OF ANALYTICAL PROCEDURES USED NOT ONLY IN DNA-SEQUENCING, BUT ALSO IN HUNTING FOR GENES RESPONSIBLE FOR GENETIC DISEASE.