NEW IMAGING MEDIA FOR IN-VIVO & IN-VITRO AUTORADIOGRAP

WE WILL DEVELOP A HIGHLY SENSITIVE IMAGING PLATE BASED ON ETPHOSPHORS AND READ-OUT SYSTEM FOR IN VIVO AND IN VITRO AUTORADIOGRAPHY. IT IS EXPECTED THAT THE PLATES WILL HAVE THE CAPABILITY OF RECORDING IMAGES PRODUCED BY BETA PARTICLEEMISSION FROM (3)H, (125)I AND (14)C, THE PRINCIPAL RADIOACTIVE TAGS EMPLOYED IN BRAIN AND WHOLE BODY IMAGING. IT IS EXPECTED THAT, IN CONTRAST TO X-RAY FILM, AT LEAST A 10-FOLD INCREASE IN SENSITIVITY WILL BE ACHIEVED, THERE WILLBE A DYNAMIC RANGE IN EXCESS OF FOUR ORDERS OF MAGNITUDE, THE RESPONSE WILL BE LINEAR OVER THIS RANGE, AND THE PLATES WILL BE REUSABLE AND WILL HAVE A TAILORABLE RESOLUTION CAPABILITY. DURING PHASE I, IMAGING PLATES WILL BE FABRICATED, IMAGING CHARACTERISTICS WILL BE MEASURED EMPLOYING (3)H, (125)I AND (14)C STANDARDS, AND READ-OUT SYSTEMS WILL BE EVALUATED FOR OBTAINING THE BEST QUALITY IMAGES. GIVEN THE SPEED-UP OF EXPERIMENTATION EXPECTED AND THE POTENTIAL FOR SUPERIOR IMAGES, SUCH IMAGING PLATES CAN REPLACE X-RAY FILM IN AUTORADIOGRAPHY APPLICATIONS. WE WILL DEVELOP A HIGHLY SENSITIVE IMAGING PLATE BASED ON ETPHOSPHORS AND READ-OUT SYSTEM FOR IN VIVO AND IN VITRO AUTORADIOGRAPHY. IT IS EXPECTED THAT THE PLATES WILL HAVE THE CAPABILITY OF RECORDING IMAGES PRODUCED BY BETA PARTICLEEMISSION FROM (3)H, (125)I AND (14)C, THE PRINCIPAL RADIOACTIVE TAGS EMPLOYED IN BRAIN AND WHOLE BODY IMAGING. IT IS EXPECTED THAT, IN CONTRAST TO X-RAY FILM, AT LEAST A 10-FOLD INCREASE IN SENSITIVITY WILL BE ACHIEVED, THERE WILLBE A DYNAMIC RANGE IN EXCESS OF FOUR ORDERS OF MAGNITUDE, THE RESPONSE WILL BE LINEAR OVER THIS RANGE, AND THE PLATES WILL BE REUSABLE AND WILL HAVE A TAILORABLE RESOLUTION CAPABILITY. DURING PHASE I, IMAGING PLATES WILL BE FABRICATED, IMAGING CHARACTERISTICS WILL BE MEASURED EMPLOYING (3)H, (125)I AND (14)C STANDARDS, AND READ-OUT SYSTEMS WILL BE EVALUATED FOR OBTAINING THE BEST QUALITY IMAGES. GIVEN THE SPEED-UP OF EXPERIMENTATION EXPECTED AND THE POTENTIAL FOR SUPERIOR IMAGES, SUCH IMAGING PLATES CAN REPLACE X-RAY FILM IN AUTORADIOGRAPHY APPLICATIONS.