SBIR/STTR Research Award
FY 2013 Contract HHSN271201300012C, SBIR-1, Topic 003, Automated Instrument for C
Award amount
$158,510Program and phase
SBIR · Phase IAward year
2013Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- DEXORGEN INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- ZNUMJ4FKRC19
- Solicitation number
- Not reported
- Topic code
- NIDA
Research abstract
In this SBIR phase I grant application, Codex BioSolutions proposes to construct a cell-based high throughput assay that measures chemical toxicity using a novel dye, m-MPI. This dye was engineered to overcome many of the drawbacks of current dyes used tomeasure mitochondrial membrane potential. The parent dye JC-1 has been used for this purpose previously. In the mitochondria, where it accumulates as aggregates, it fluoresces red, whereas in the cytoplasm where it is a monomer, it fluoresces green. However, JC-1 is difficult to use because it has very low water solubility which makes using its differential fluorescent properties difficult. Our dye, m-MPI has increased solubility allowing easy quantitative assessment of MMP status simply by calculating theratio of red/green fluorescence. m-MPI can also be used with cells that do not work with JC-1 (such as primary cells) due at least in part to its increased sensitivity. We believe our assay will more accurately assess hazards in a shorter time and with less cost. PUBLIC HEALTH RELEVANCE
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- DEVELOPMENT OF NOVEL PDE4B INHIBITORS TO TREAT ALCOHOL USE DISORDER (SBIR PHASE II)
- The purpose of this contract is to identify several cellular factors that have a major impact on production of a full-length HIV-1 envelope trimer without altering its native antigenic properties.
- Novel Strategies to Improve Production of a Full Length Native HIV Env Spike
- DEVELOPMENT OF NOVEL PDE B INHIBITORS TO TREAT ALCOHOL USE DISORDER
- Topical Application of Hsp90 alpha Bio-modulator to Promote Healing of Soft Tissue Injuries
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Wearable Wireless Respiratory Monitoring System that Detects and Predicts Opioid Induced Respiratory Depression
- Building and testing the Life Enhancement and Advocacy Programming digital training tool (LEAPLink) to better serve people with lived experience of homelessness and substance use disorder
- A digital intervention to decrease self-stigma among pregnant and postpartum women with opioid use disorder
- Development of medication for the treatment of respiratory depression due to opioid (prescribed or illicit) overdose/multidrug (polysubstance) overdose in a hospital or community setting.
- Creation and Validation of the Dose-Opioid-Source Evaluation tool (DOSE) - a Robust Opioid Use Clinical Outcome Assessment for Qualification as an FDA Medical Device Development Tool (MDDT)
Research funding history
7 SBIR/STTR records share this UEI (2011–2019). Reported award amounts total $2,928,465. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, Department of Defense