PREDICTIVE BIOMARKERS OF ADVERSE REACTIONS TO PROSTRATE CANCER RADIOTHERAPY

The overall objective of this project is to advance the development of a clinically usefully multiplex assay todetect biomarkers of radio sensitivity that will identify subsets of prostate cancer patients for whichradiotherapy should be contraindicated This assay will be capable of predicting the risk of developingadverse effects principally urinary morbidity and rectal injury resulting from radiotherapy treatment ofprostate cancer Our studies have identified SNPs in multiple cohorts that are strongly associated withadverse effects resulting from radiotherapy The goal of the current project is to validate these SNPs in anindependent cohort using a multiplex SNP assay The technical objectives of this project are Evaluatethe clinical outcome associations with all SNPs p value andlt in Phase I in an independent clinical patientset Expand the content of prototype multiplex assay to detect relevant SNPs discovered in Phase I Test the ability of the prototype assay to predict adverse outcomes to prostate radiotherapy and Obtainquantitative and qualtitative data describing provider preferences for receiving and using genetic informationin radiotherapy treatment planning