SBIR/STTR Research Award
PRODUCTION OF PEPTIDE PHARMACEUTICALS IN PLANTS
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1988Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Dna Plant Technologi
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE GENE WHICH ENCODES HUMAN GROWTH HORMONE WILL BE ENGINEERED FOR HIGH EXPRESSION IN PLANT CELLS BY FUSIONS TO STRONG PROMOTERS FROM PLANTS. THESE CHIAMERIC GENES WILL BETRANSFERRED TO PLANT CELLS BIA THE AGROBACTERIUM TRANSFORMATION SYSTEM, AND REGENERATED TRANSGENIC PLANTS WILL BE PRODUCED. SUCH PLANTS WILL BE ASSAYED TO DETERMINE THE LEVELS OF HGH MRNA, AND PROTEIN WHICH IS PRODUCED, AND WHETHER CORRECT PROCESSING OF THE PRECURSOR PROTEIN HAS OCCURRED, NAMELY REMOVAL OF A SIGNAL PEPTIDE, AND INTRODUCTION OF TWO DISULFIDE BONDS. THIS APPROACH, IF SUCCESSFUL, WILL PROVIDE A COST EFFECTIVE ALTERNATIVE TO THELARGE SCALE AND ECONOMIC PRODUCTION OF PROTEIN PHARMACEUTICALS USED IN MAMMALIAN HEALTH CARE.
Technology keywords
Not reported