FALCIPAIN INHIBITORS AS ANTIMALARIAL DRUGS

Not Available Modern protective clothing provides effective protection from chemical agents in most situations but can impose significant thermal stress on the wearer under some battlefield conditions. Currently, design of protective garments relies on slow and costly trial-and- error laboratory testing to assess performance. The proposed project will develop advanced computational models for a clothed human that will enable the military to develop new and improved protective clothing more rapidly and less expensively. The models utilize state- of-the-art computational fluid dynamics (CFD) software to model the transport and sorption of chemical agents and the heat transfer due to convective, diffusive, and phase change through the clothing layers. In Phase I, proof-of-principle models of a static clothed human will be developed and demonstrated During Phase II, complete moving grid models for a clothed soldier will be developed. BENEFITS: The proposed models will reduce the cost and time required to develop new protective garments while helping to improve their performance. These models will have direct and immediate application in development of improved garments for protection from chemical threats and can be used in modeling other military clothing. Commercially, the models have application in the design of industrial garments and advanced outdoor clothing.