SBIR/STTR Research Award

Biochemistry of Oligomer/Pyrroloindole Conjugates

Award identifier 384cf20f54a7c4bb7ed3e78b6cf7553ff919fafa6f549f99f8e73010ddeeb0a3Awarding agency Department of Health and Human Services

Award amount

$93,147

Program and phase

SBIR · Phase I

Award year

1995

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
Epoch Pharmaceuticals, Inc.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

We have developed the chemistry to conjugate a pyrroloindole tripeptide (CDPI3) analog of CC-1065 t3' ends of any oligodeoxyribonucleotide (ODN). The resultant conjugates hybridize sequence specificaDNA and RNA strands, yet do not interact with double-stranded DNA. The conjugated CDPI3 moiety can sstabilize short duplexes by binding to the minor groove. In light of these results, we will evaluateconjugates as anti sense and antigene agents. The ability of ODN-CDPI3 conjugates to sequence specifreplication, transcription and translation will be investigated using simple in vitro model systems.studies will be initiated to evaluate the potential of these modified ODNs for use as anti sense, anagents.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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