Prevention of erectile dysfunction following prostate cancer radiotherapy

DESCRIPTION (provided by applicant): The aim of this proposal is to evaluate BIO 300 as an effective therapy to prevent and/or mitigate the erectile dysfunction (ED) that is commonly observed following radiotherapy (RT) for prostate cancer. Prostate cancer is the most common cancer among men in the United States. Approximately half of prostate cancer patients will undergo RT as a part of their treatment. Even though 5 year survival rates are high (gt99.2%), about half of the men who receive RT will develop ED within 5 years. Radiation-induced ED remains an unmet medical need that severely impacts the sexual health-related quality of life of cancer survivors, especially younger men. Significantly, possible loss of sexual function plays an important rolein treatment-related decisions for men with prostate cancer. Humanetics Corporation is developing BIO 300 oral suspension to treat the delayed effects of acute radiation exposure (DEARE), including radiation-induced pneumonitis and fibrosis. BIO 300 ha