THE AIM OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL ANTIBODYCONJUGATES FOR USE IN THE RADIOIMMUNODETECTION OF TUMORS.

THE AIM OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL ANTIBODYCONJUGATES FOR USE IN THE RADIOIMMUNODETECTION OF TUMORS. IN RESPONSE TO THE PROBLEMS ASSOCIATED WITH THE ANTIBODY- DTPA-RADIOMETAL IMAGING METHODOLOGIES WITH REGARD TO LIVER DEPOSITION OF THE METAL, A NUMBER OF MORE SPECIFIC CHELATORSWILL BE INVESTIGATED. BASED ON THE CAPABILITY OF THE CHELATORS TO TIGHTLY BIND THE METAL AND BECAUSE OF THEIR GREATER LIPOPHILIC CHARACTER AND LACK OF EXCESS FUNCTIONALITY, ENHANCEMENT OF MEMBRANE TRANSPORT OF THE LIGAND-METAL COMPLEX IS TO BE EXPECTED. THE OVERALL SYNTHETIC STRATEGY WILL ALLOW A LARGE NUMBER OF ALTERNATIVESTO BE CONSIDERED IN THE FUTURE, WHILE THE COMPOUNDS' CLOSE CORRELATION WITH UBIQUITOUS NATURAL PRODUCTS WOULD NOT INDICATE ANY FUTURE CYTOTOXIC PROBLEMS. ANTIBODY CONJUGATION WILL FOLLOW PROTOCOLS ESTABLISHED IN THESE LABORATORIES AND ELSEWHERE.