A Universal Technique for Antimicrobial Surface Preparation Using Quaternary Ammonium-Functionalized Dendrimers

A novel, environmentally benign antimicrobial surface modification based on immobilized quaternary ammonium-functionalized dendrimers is proposed for the prevention of biofilm formation. Dendrimers are unique nanomaterials that have attracted attention as possible antimicrobial agents due to their compact structure, high local charge density of functional surface groups, unique carrier properties, and biofriendly nature. High local concentrations of active groups are extremely beneficial in terms of potency, reduced toxicity, and increased duration of action. Lynntech, Inc., proposes to: (1) synthesize and characterize a novel series of quaternary ammonium-functionalized dendrimers; (2) evaluate their effectiveness as biocides; (3) develop a surface treatment that can immobilize the dendrimers, be covalently attached to a variety of polymers, and be formed on either or both the inner and outer surfaces of complex geometries; and (4) evaluate the physical and biocidal properties of the materials modified with the immobilized dendrimers. The many applications of this technology are what make it so attractive. Because the antimicrobial surface modification can be applied to a variety of plastics preformed into complex shapes, its use is virtually unlimited. Lynntech, Inc., envisions this technology being used: (1) for in situ soil and other monitors; (2) for dental and other water lines; (3) to form antimicrobial fabrics; (4) to treat medical devices; (5) to produce heavy-metal-free antifouling coatings; (6) in water filtration and other membranes; (7) for glove and respirator materials; and (8) in biowarfare defense. Many consumer products could result from this technology, especially in the medical and food and beverage preparation and packaging fields.