SBIR/STTR Research Award
A DEVICE FOR REPAIR OF MUCOGINGIVAL TISSUE
Award amount
$110,000Program and phase
SBIR · Phase IAward year
2001Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- ACELL, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
DESCRIPTION: This research proposes to evaluate the use of urinary
bladder-extracellular matrix (UBM-ECM) for the repair of diseased mucogingival
tissue. Cells harvested from either attached gingiva or buccal mucosa will be
used to seed either of these substrates and the resulting engineered tissue
will ultimately be tested for their histogenic potential in the appropriate
mucosal sites in dogs. Since the state of hydration of the substrate may be a
factor in the potential for cellular differentiation and proliferation, an
initial study will be done to test the hydrated state versus the freeze dried
state in this regard. The strength of the final tissue engineered product will
be mechanically tested for its ultimate suture strength prior to implantation
in the dog model.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
Technology keywords
Not reported