SBIR/STTR Research Award
Casein Kinase 1 Inhibitors for Treatment of Autism
Award amount
$349,610Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- INTRA-CELLULAR THERAPIES, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- VA5JXLCJHDK7
- Solicitation number
- PA11-133
- Topic code
- NIMH
Research abstract
PAR-11-133 - PI, Gretchen L. Snyder, PhD Casein Kinase I Inhibitors for Autism Project Summary/Abstract Autism is a neurodevelopmental disorder characterized by abnormal social interaction, deficits in interpersonal communication, and repetitive stereotyped behaviors with a number of individually- occurring associated symptoms, including intellectual impairment, anxiety, seizures, hyperactivity, hyper- or hypo-responsiveness to sensory stimulation, sleep disruption, and gastrointestinal abnormalities. It isnoteworthy that hyperactivity, impulsivity, and inattention-core features of attention deficit hyperactivity disorder (ADHD)-occur as associated symptoms in a high percentage (41-78%) of autistic individuals. As a complex, multi-symptom disorder, a largenumber of gene mutations (heritable and de novo) as well as environmental and epigenetic factors are likely involved in the expression of autism. Currently, there is no cure or satisfactory treatment for autism. New therapeutic agents that would effective
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Development of PDE2 Inhibitors for Treatment of Anxiety/Depression in Autism/Schizophrenia
- Novel PDE Inhibitors for Treatment of Cognitive Dysfunction in Schizophrenia
- Development of Novel Glutamate Antagonists as Neural Protectants against Organophosphorus (OP) Compounds
- Development of Pre- and Post-Exposure Neural Protectants Against Organophosphorus (OP) Compounds Based on Novel and Specific Biochemical Markers of OP
- PHOSPHOPROTEOME ANALYSIS OF ANTIDEPRESSANT DRUGS
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Anise Health: Digital Mental Health for Asian Americans
- iKinnect2.0 for Juvenile Justice Involved Youth at Risk for Suicide Diversity Supplement
- The Development and Systematic Evaluation of an AI-Assisted Just-in-Time-Adaptive-Intervention for Improving Child Mental Health
- Scalable, non-dissociative single-cell RNA sequencing for mapping the brain in health and disease
- A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration
Research funding history
6 SBIR/STTR records share this UEI (2003–2016). Reported award amounts total $4,693,502. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, Department of Defense