SBIR/STTR Research Award

ASSAY FOR IDENTIFYING ANGIOGENIC DRUG TARGETS

Award identifier 450b50cc370119ddc671477eaa39b26f142b8b7910d6153c46117646cbdc8f95Awarding agency Department of Health and Human Services · National Institutes of Health

Award amount

$149,974

Program and phase

SBIR · Phase I

Award year

2001

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Award details

Awarding agency
Department of Health and Human Services
Branch
National Institutes of Health
Recipient company
PHYLONIX PHARMACEUTICALS, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

DESCRIPTION: (Applicant's Description) Our overall aim is to use a molecular approach to isolate new genes involved in angiogenesis. We will treat zebrafish embryos with drugs and identify genes using subtractive library technology. Angiogenesis has been shown to be necessary for tumor growth and inhibition of vessel formation appears to be an excellent target for cancer therapy. The whole animal zebrafish bioassay will streamline the drug development process for cancer and heart disease. PROPOSED COMMERCIAL APPLICATION: More that 20 antiangiogenic compounds are in clinical trials. Angiogenesis has been implicated in a number of diseases including cancer, heart disease, diabetes, ulcers and some autoimmune diseases. The market potential for screening services is estimated to be over $100M.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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