THE CONTRACTOR SHALL DEVELOP A NOVEL NANOPARTICLE DELIVERY SYSTEM TO ELICIT POTENT AND LONG-LASTING ANTIBODY RESPONSE AND BROADLY NEUTRALIZING ACTIVIT

Particle-based Co-delivery of HIV immunogens as Next-generation HIV Vaccines: Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, self-amplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies. The objective of this contract is to develop a novel nanoparticle delivery system to elicit potent and long-lasting antibody response and broadly neutralizing activity against HIV.