SBIR/STTR Research Award

Screening Assay for Platelet ADP Receptor Antagonists

Award identifier b037b10888143c316a57a82ff8882f0fda81a0ac16b7bc346dda20dae1c1b2a8Awarding agency Department of Health and Human Services

Award amount

$85,575

Program and phase

SBIR · Phase I

Award year

1995

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
COR THERAPEUTICS, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

ADP activates and promotes aggregation of platelets in hemostasis and thrombosis. This applicationdevelop a high-throughput screening assay to identify novel ADP-receptor antagonists. The assay willof a high-affinity radioligand to using 96-well microtiter plates. The assay will be validated for ssynthetic compounds. This assay may lead to a Phase II proposal for the performance of high-throughpidentification and characterization of ADP receptor antagonists. Based on this lead, novel orally acmay be developed for the prevention and treatment of cardiovascular diseases.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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