Inhibition of Tendon Adhesions By Adcon-T

Scars form after tendon injury. It binds the tendon and prevents it from gliding freely, resultingin diminished movement in a high percentage of patients. Prophylactic application of an agent thatinhibits adhesion formation would improve the outcome of these patients. We have developed a seriesof proprietary materials that inhibit scar formation. The purpose of the research is to develop a chickenmodel and to test ASCON-T, one such scar inhibiting agent. The chicken is chosen as a preclinicalmodel because the movement of a chicken foot mimics the movement of the human hand. Specifically,the investigators will develop a reproducible model for injury of and immobilization of the tendon. Theywill develop test methods for evaluating the resulting scar. Once this model is developed in Phase I, theywill test ASCON-T for safety and efficacy in Phase II.