Improved Protein Manufacturing in Insect Expression Systems

Chesapeake PERL is a contract manufacturing company using the baculovirus expression system for mass production of proteins in lepidopterous insect larvae. PERL's automated in-line insect mass rearing and inoculation systems enables the production oflarge quantities of complex, biologically fully functional proteins. The baculovirus expression system as developed in the eighties and nineties is a versatile system for protein expression at small and intermediate quantities of protein in insect cellscultured in flasks or bioreactors. We propose a series of improvements in the system aimed at developing more convenient and rapid methodology for abundant expression of both intermediate and large quantities of functional proteins in intact, livinglepidopteran larvae. to be added