SBIR/STTR Research Award
EXPRESSION OF FOREIGN GENES IN WHOLE INSECTS USING RECOMBINANT BACULOVIRUS
Award amount
$210,000Program and phase
SBIR · Phase IIAward year
1987Award details
- Awarding agency
- Department of Agriculture
- Branch
- Not reported
- Recipient company
- Microgenesys Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
BACULOVIRUSES HAVE GREAT POTENTIAL AS INSECT CONTROL AGENTS BY THEIR INHERENT SELECTIVITY AND SAFETY. RECOMBINANT BACUL OVIRUSES EXPRESSING FOREIGN GENES ENCODING FOR INSECTICIDAL PROTEINS SHOULD BE CONSIDERABLY MORE EFFECTIVE BIOLOGICAL CONTROL AGENTS THAN WILD-TYPE VIRUSES IN BOTH FIELD EFFICACYAND HOST RANGE. THE AIM OF THE PROPOSED RESEARCHIS TO INVESTINGATE THE BIOLOGY AND EFFECTS OR RECOMBINANT VIRUSES IN WHOLE INSECTS. AN EASILY ASSAYABLE GENE (B-GALACTOSIDASE), SEVERAL ACMNPV RECOMBINANTS, AND SUBCEPTIBLE LEPIDOPTERAN LARVAE WILL BE USED A MODEL MATERIALS. SUCH QUESTIONS AS THE TIME COURSE, SITE AND QUANTITY OF GENE EXPRESSION AND THE STABILITY OF VIRUS RECOMBINANTS FOLLOWING REPEATED PASSAGES, WILL BE ANSWERED.
Technology keywords
Not reported