SBIR/STTR Research Award
DNA AMPLIFICATION FOR THE DIAGNOSIS OF GENETIC DISEASE
Award amount
$500,000Program and phase
SBIR · Phase IIAward year
1990Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Integrated Genetics Inc
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THIS RESEARCH INVOLVES THE APPLICATION OF IN VITRO DNA AMPLIFICATION AND SPECIFIC OLIGONUCLEOTIDE PROBES TO THE CLINICAL ANALYSIS OF GENETIC DISEASE. THE GOAL OF PHASE I OF THIS PROJECT IS TO SEQUENCE THREE OF THE MORE INFORMATIVE DNA PROBES LINKED TO CYSTIC FIBROSIS. THIS SEQUENCE INFORMATION WILL BE USED TO DESIGN OLIGONUCLEOTIDE PRIMERS FOR EFFICIENT AMPLIFICATION AND SEQUENCE-SPECIFIC OLIGONUCLEOTIDE PROBES TO DETECT GENETIC POLYMORPHISMS IN THE AMPLIFIED DNA. THE FEASIBILITYOF THIS METHOD OF ANALYSIS FOR THE LARGE-SCALE DIAGNOSIS OF GENETIC DISEASE WILL THEN BE EVALUATED. THE SPEED AND ACCURACY OF THIS TECHNIQUE IS EXPECTED TO HAVE SIGNIFICANT EFFECTS ON THE CLINICAL DETERMINATION OF THE INHERITANCE OF GENETIC DISEASE.
Technology keywords
Not reported