Translocations Using Gel Microdrops

We will combine gel microdrop encapsulation technology with high complexity chromosome painting proflow cytometry to generate enriched populations of aberrant chromosomes. Model mouse and human systecolor painting probes will be used to investigate the feasibility of sorting microencapsulated chromunbalanced translocations. Genetic aberrations such as translocations are implicated in a variety ofprogression. This research represents a significant extension of FISH technology by making it possibbased on DNA sequence. As molecular diagnostics continue to evolve, automated methods for clinical ain importance. This technology is expected to be used initially as a research tool, primarily beneficommunity. In the future, clinical diagnostic and specialty cytogenetic reference labs will be usersand development will be expanded to include analysis of other aberrations such as deletions. As a recompany plans to increase the number of test kits available for use with its chromosome isolation anThese products will be sold to researchers and the technology will be licensed for use in clinical d