SBIR/STTR Research Award
Ultrahigh-throughput Identification of Molecular Targets of Natural Products
Award amount
$225,000Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- NEWOMICS INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- LMKSNZ862R36
- Solicitation number
- AT14-001
- Topic code
- NCCIH
Research abstract
DESCRIPTION (provided by applicant): Natural products are rich sources for potential drugs. To accelerate drug discovery from natural products, it is imperative to identify their molecular targets, and mechanistically elucidate their bioavailability, toxicity, and therapeutic effects. However, there remain several challenges in the field. Among them, there is currently no technical platform that could perform mechanistic studies from the hits to leads using the small volumes of samples that are typically encountered in quantitative high-throughput screening (qHTS). In response to RFA- AT-14-001, Newomics Inc. proposes to develop a multi-omics platform for high-throughput and high-content bioassays of natural products. The core technology will be based onNewomics' breakthrough silicon- microfluidic-chip, the multinozzle emitter array chip (MEA chip-2012 RandD100 award), which enables liquid chromatography-nanoelectrospray ionization mass spectrometry (LC-nanoESI/MS)-based, highly sensitive, highly spec
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Multispray Technology for Studying Biomolecular Interactions
- Picoelectrospray Ionization Mass Spectrometry for Top-down Proteomics
- Senescence-Chips for Radiation Biodosimetry
- AD-MS Chips for Biofluids-Based Diagnosis of Alzheimer's Disease
- Ultrahigh throughput Identification of Molecular Targets of Natural Products
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Using scalable ultrasonic nano-emulsification to improve pharmacokinetic properties of the natural product curcumin.
- Botanical Drug for Chemotherapy Induced Nausea and Vomiting
- Leveraging Large Scale Bioinformatics and AI for Natural Product Drug Discovery and Target Selection
- Member Engagement Application for Personalized Arts-Based Social Prescriptions
- Evaluation of a novel soil-derived Mycobacterium as a nutritional supplement to promote stress resilience
Research funding history
14 SBIR/STTR records share this UEI (2012–2025). Reported award amounts total $14,707,662. Reported amounts are not federal obligations.
Phases: Phase II, Phase I
Agencies: Department of Health and Human Services