IN VIVO SKIN TARGETED GENE THERAPY BY ELECTROPORATION

Not Available Developing a new capability to monitor accumulation of fatigue damage prior to crack initiation in critical aircraft structures is proposed. New permanently mountable eddy current sensor arrays, called MWM-Arrays, have been developed by JENTEK and have been demonstrated on tension-tension fatigue test coupons to provide continuous online monitoring of crack initiation and growth. This effort will extend and further develop this capability both for detection of fatigue damage (including the formation of persistent slip bands prior to microcrack formation) and for specific fatigue monitoring applications on Air Force aircraft. The objectives of the Phase I effort are to: (1) establish the MWM-Array fatigue damage detection threshold for a selected alloy, (2) define requirements for a specific fatigue-critical area on a selected aircraft, (3) demonstrate the required fatigue detection feasibility for the selected application, and (4) determine the feasibility of implementing a portable system based on the MWM/Grid Methods for field/depot use, including both permanently mounted and wide-area imaging modes. This Phase I effort and follow-on Phase II effort will include fatigue coupon studies to determine detection threshold and implementation of fieldable solutions for Air Force aircraft. Phase II will include development and delivery of a portable system for field/depot inspections.