SBIR/STTR Research Award
Method for Isolation and Microassay of Lipoprotein (A)
Award amount
$592,416Program and phase
SBIR · Phase IIAward year
1997Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- MICRONIX, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
Lipoprotein(a) [Lp(a)] has been labelled the most atherogenic lipoprotein in man. Current laboratorLp(a) employ immuno-quantitation of its apolipoprotein [apo(a)]. Because these methods are hamperedto plasminogen, apo(a) isoform dependence, antibody heterogeneity, and lack of standardization, noneapproved. One third of Lp(a)'s mass is cholesterol, and only one tenth is apo(a). We will develop olaboratory, and a semi-quantitative screening method for Lp(a) cholesterol [Lp(a)-C]. The methods exhigh content of carbohydrate, e.g. sialic acid. Lp(a) is separated from other lipoproteins by bindincarbohydrate structures to a specific solid-supported lectin, and analyzed by highly sensitive enzym
Technology keywords
Not reported