RM/NEI DRY POWDER INHALATION THERAPY FOR CYSTIC FIBROSIS

Not Available Micro Oscillator Inc. (MOI) proposes to develop a low operating power (drawing less than 1 mA) timer base capable of maintaining high frequency accuracy at shock loads up to 100,000 G. The timer base will use a circuits based on a patented CMOS I.C clock oscillator developed by MOI that is already being used by the Military in high shock weapon applications. This oscillator maintains ¿ .5% accuracy and appears capable of meeting the 100,000 G shock requirement as is but draws 5 mA. The goal of proposed Phase II effort will be to build the timer base system as a single I.C. The circuit design of the breadboard units built using commercially available parts during Phase I will be modified to permit the equivalent circuits that are compatible with I.C. process and fabrication rules to be built as an I.C. As an option, the I.C. will be fabricated using a silicon on Insulator CMOS process that will permit reliable performance up to +225¿C and limited operation to +300¿C.