SBIR/STTR Research Award
MONOCLONAL ANTIBODIES TO HUMAN PARAINFLUENZA VIRUES 1 AND 2
Award amount
$500,000Program and phase
SBIR · Phase IIAward year
1988Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- MOLECULAR ENGINEERING CORP.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
MOLECULAR ENGINEERING ASSOCIATES, INC. PROPOSES TO DEVELOP APANEL OF MONOCLONAL ANTIBODIES TO HUMAN PARAINFLUENZA VIRUS TYPES 1 AND 2. ANTIBODIES WILL BE EVALUATED BY NEUTRALIZATION, HEMAGGLUTINATION INHIBITION, NEURAMINIDASE INHIBITION, FUSION INHIBITION, ELISA, IMMUNE PRECIPITATION, WESTERN BLOT, AND IMMUNOFLUORESCENCE ASSAYS. THE OBJECTIVE OF THE PHASE I PROPOSAL IS TO IDENTIFY MONOCLONAL ANTIBODIESSPECIFIC TO THE SURFACE GLYCOPROTEINS (HN AND F) OF THESE VIRUSES, AS WELL AS TO OTHER MAJOR VIRION POLYPEPTIDES. THELONG-TERM OBJECTIVE IS TO UTILIZE SUCH ANTIBODIES FOR DEVELOPMENT OF IMPROVED VACCINES AND RAPID DIAGNOSTIC TESTS.
Technology keywords
Not reported