SBIR/STTR Research Award
FEASIBILITY STUDY--TAXOL FROM PLANT CELL CULTURE
Award amount
$49,981Program and phase
SBIR · Phase IAward year
1991Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Phyton Catalytic, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE LONG TERM OBJECTIVE OF THIS PROJECT IS TO PRODUCE TAXOL IN BULK USING A PLANT CELL CULTURE PROCESS. PREVIOUSLY PROVEN AS WELL AS NOVEL PRODUCTIVITY-ENHANCEMENT STRATEGIES WILL BE DEVELOPED IN A COMPREHENSIVE AND INTEGRATED MANNER. THE SPECIFIC AIM OF PHASE I RESEARCH IS TO ESTABLISH THE FEASIBILITY OF USING PLANT CELL CULTURES FOR TAXOL PRODUCTION BY ACCOMPLISHING FOUR ENABLING OBJECTIVES: (1) TRANSFER OF PRODUCTIVITY FROM CALLUS TO SUSPENSION WILL BE VERIFIED. (2) OVER 200 CELL LINES WILL BE SCREENED FOR TAXOL AND OTHER TAXANES. (3) CONDITIONS FAVORING RAPID GROWTH WILL BE ESTABLISHED. (4) KINETICS OF GROWTH AND PRODUCT FORMATION WILL BE STUDIED.
Technology keywords
Not reported