SBIR/STTR Research Award
PURIFICATION OF AN AUTOCRINE ANGIOGENESIS INHIBITOR
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1987Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- California Biotechnology, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
A PROTEIN HAS BEEN IDENTIFIED FROM A CULTURED CELL LINE WHICH INHIBITS THE GROWTH OF CAPILLARY ENDOTHELIAL CELLS IN VITRO. THIS PROTEIN WILL BE PURIFIED FROM CONDITIONED GROWTH MEDIUM AND USED IN IN VITRO AND IN VIVO MODEL SYSTEMSTO TEST ITS ABILITY TO INHIBIT THE FORMATION OF NEW CAPILLARIES. THIS IS THE FIRST STEP TOWARD DEVELOPING A THERAPY THAT WILL BE USED IN THE TREATMENT OF SOLID TUMORS, VARIOUS RETINOPATHIES, PSORIASIS, ARTERIAL OCCLUSIVE DISEASE, AND IN BIRTH CONTROL, ALL OF WHICH INVOLVE EITHER NEOVASCULARIZATION OR GROWTH OF ENDOTHELIAL CELLS THEMSELVES.
Technology keywords
Not reported